Microdosing and Medication

March 1, 2025

Artsy Shot: Blue or Red Pill?

An article by Kate

Executive Summary

Does microdosing preclude the use of (conventional) medications? Fortunately, someone has already looked into this question. The results for all medications, supplements, and recreational drugs that show neither side effects nor interactions when combined with microdosing are now fully listed here. Additionally, critical self-reflection and observation of one's own well-being are essential.

Microdosing, the practice of taking small amounts of psychedelic substances such as LSD or psilocybin, has gained popularity in recent years. Proponents report a variety of positive effects, including increased creativity, improved mood, and enhanced focus. But what happens when microdosing is combined with conventional medications or dietary supplements? Dr. James Fadiman, also known as "the Godfather of Microdosing," and Dr. Sophia Korb have compiled a comprehensive list showing which medications, supplements, and drugs have shown no negative side effects when combined with microdosing. Nevertheless, this should not be considered a definitive safety guarantee or medical advice. Especially when taking multiple medications or having existing health conditions, it is essential to consult a doctor or psychiatrist who is knowledgeable about the interaction of psychedelics and medications.

☝🏻 Disclaimer: Please note our Risk Warnings.

Free from Side Effects: Important Information on Microdosing and Medications

The following list refers exclusively to microdosing with LSD and psilocybin. It is recommended to exercise particular caution with other substances. If your medication is not on the list, it means that there is currently not enough data to confirm the safety and effectiveness of the combination.

Painkillers:

Acetaminophen/Paracetamol (Tylenol)
Aspirin
Codeine
Dihydrocodeine (Co-dydramol)
Hydrocodone (Vicodin, Norco)
Ibuprofen (Advil, Motrin)
Naproxen (Aleve)

Cardiac/Blood Pressure Medications:

Amiodarone (Cordarone, Nexterone)
Hydrochlorothiazide (HCTZ, HCT)
Lisinopril (Prinivil, Zestril)
Losartan (Cozaar)
Spironolactone (Aldactone)
Telmisartan (Micardis, Actavis)
Valsartan (Diovan)
Ramipril (Tritace)

Contraceptives:

Aubra
Hormone pills
Marvelon
Mirena
Nuvaring
Tricyclen

Antacids:

Ranitidine (Zantac)

Antibiotics:

Clindamycin (Cleocin, Dalacin, Clinacin)
Doxycycline
Minocycline (Minocin, Minomycin, Akamine)
Penicillin (Bicillin)

Antifungals:

Fluconazole (Diflucan, Celozole)

Attention Deficit/Hyperactivity Disorder (ADHD/ADD):

Amphetamine (Adderall)
Bupropion (Wellbutrin)
Dextroamphetamine (Dexedrine, Metamina, Attentin, Zenzedi, Procentra, Amfexa)
Lisdexamfetamine (Vyvanse)
Methylphenidate (Ritalin, Biphentin)
Modafinil (Provigil)

Sleeping Pills:

Zopiclone (Zimovane, Imovane)
Melatonin
Zolpidem (Ambien, Stilnox)

Antihistamines:

Cetirizine (Zyrtec)
Diphenhydramine (Benadryl, Gravol)
Loratadine (Claritin)
Ranitidine (Zantac)

Benzodiazepines (Anxiety, Sleep, Seizures):

Alprazolam (Xanax)
Clonazepam (Klonopin)
Diazepam (Valium)
Flurazepam (Staurodorm)
Lorazepam (Ativan)

Other Anxiolytics:

Etizolam
Propranolol

Parkinson's Medications:

Levodopa
Pramipexole

Cholesterol Medications:

Atorvastatin (Lipitor)
Rosuvastatin (Crestor)
Simvastatin (Zocor)
Statins

Racetams:

Aniracetam
Phenylpiracetam
Piracetam

Mood Stabilizers and Antipsychotics:

Aripiprazole (Abilify)
Buspirone (Buspar)
Lamotrigine (Lamictal)
Quetiapine (Seroquel)

Diabetes:

Metformin (Glucophage)

Anticonvulsants:

Baclofen (Lioresal)
Carbamazepine (Tegretol)
Cyclobenzaprine (Flexeril)
Gabapentin
Mirtazapine
Sodium valproate
Tizanidine (Zanaflex)
Primidone
Topiramate

Thyroid Medications:

Methimazole or Thiamazole

Antidepressants:

Bupropion (Wellbutrin)
Citalopram (Celexa)
Desvenlafaxine (Pristiq)
Doxepin (Sinequan)
Duloxetine (Cymbalta)
Escitalopram (Lexapro)
Paroxetine (Paxil)
Sertraline (Zoloft)
Venlafaxine (Effexor)

GERD:

Esomeprazole (Nexium)
Pantoprazole (Protonix)
Ranitidine (Zantac)

Respiratory (Asthma, COPD):

Salbutamol (Albuterol)
Cetirizine (Zyrtec)
Beclomethasone (Clenil Modulite)
Montelukast (Singulair)

Antiviral Medications:

Nitazoxanide

Recreational Drugs:

Alcohol
Amphetamine (Speed)
Heroin
Kratom
Marijuana (Cannabis)
Nicotine

Anti-inflammatories:

Mesalazine (Octasa)

Immunosuppressants:

Hydroxychloroquine (Quensyl)

Erectile Dysfunction:

Tadalafil (Cialis)

Alcohol Addiction Treatment:

Acamprosate (Campral)
Disulfiram (Antabuse)
Naltrexone

Hormones and Steroids:

Norethindrone Acetate-Ethinyl
Estradiol
Prednisone (Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone)
Estrogen (Premarin)
Progesterone (Prometrium, Utrogestan, Endometrin)
Testosterone
Levothyroxine (Synthroid)
Naturethroid
Dexamethasone
DHEA
Spironolactone (Aldactone)

Supplements:

5-HTP
Albizia
Ashwagandha
B100
BCAAs
Biotin
Brahmi
Bromelain
Caffeine
Calcium
Cayenne
Chaga
Chlorophyll
Choline
CILTEP
CoQ10
Cordyceps
Creatine
Eleuthero
EPA/DHA
Fish oil
Ginseng
Glucosamine
Iodine
Iron
Kelp
Kratom
L-Theanine
Lemon Balm
Lion's Mane
Maca
Magnesium
MCT
Methylsulfonylmethane (MSM)
Milk Thistle
Multivitamins
Omega 3/6/9
Passionflower
Phosphatidyl
Probiotics
Pycnogenol
Reishi
Rhodiola
Rosacea
Selenium
Shatavari
Skullcap
St. John's Wort
Taurine
Tulsi
Turmeric (Curcumin)
Turkey Tail
Twynsta
Vitamin B6
Vitamin B12
Vitamin D3
Vitamin K
Vitamin C
Vitamin K2
Vitamin D
Zinc
Zinium

Here are the fitting words from James Fadiman, to whom we owe this comprehensive list:

You have been attuned over millions of years to seek harmony with the natural world, to be curious about your own mind, and to recognize the fundamental unity of which you are a part. Whether you ever choose to use psychedelic experiences as part of your self-discovery, that decision should be an informed one.

As always, we appeal to the personal responsibility of all interested parties – no one knows your body better than you do!

And if you have now determined that the medications you are taking do not pose negative side effects or contraindications for psychedelics, then we recommend the following articles:

Relevant to microdosing: Microdosing 101
If you are interested in larger trips: Acid 101 (LSD Guide)
If you want to get oriented in the world of psychedelics first: The Magical Psychedelics Glossary

FAQ on Microdosing and Medications

What are the risks of combining microdosing and medications?

The risks depend heavily on the type of medication and the individual's health situation. Even if some combinations are considered unproblematic, interactions with microdosing and medications can occur. Anyone taking microdosing and medications simultaneously should definitely discuss this with a doctor.

Are there any medications that should not be combined with microdosing at all?

There are medications that strongly affect the serotonin balance, which can be problematic. These include certain antidepressants or MAO inhibitors. Therefore, the combination of microdosing with medications should always be clarified with professional advice.

How does microdosing affect the effectiveness of conventional medications?

Microdosing can influence the absorption or breakdown of certain medications in the body. This means that medications can either be weaker or stronger. Medical supervision is therefore advisable when combining microdosing and medications.

Can I use microdosing with medications even with chronic illnesses?

Caution is advised in chronic illnesses such as diabetes, high blood pressure, or epilepsy. In these cases, it is important to carefully check the combination of microdosing and medications and to medically clarify possible interactions.

What role does dosage play in microdosing and medications?

Dosage is an important factor: both with psychedelic substances and classic medications, noticeable effects are possible even at small amounts. Therefore, it is important to always dose microdosing with medications carefully and to closely observe your own reaction.